Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy qualit...
Colorectal cancer is one of the most common malignancies in the world. A family history of colon ca...
Background and study aims: Patients with Lynch syndrome may develop colorectal cancer (CRC), despite...
Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are diff...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Regular colonoscopy even with short intervals does not prevent all colorectal cancers (CRC) in Lynch...
Background and objective: Despite intensive colonoscopic surveillance, a substantial proportion of L...
Despite colonoscopic surveillance, Lynch syndrome patients develop colorectal cancer (CRC). Identifi...
Colorectal cancer is one of the most common malignancies in the world. A family history of colon ca...
Background and study aims: Patients with Lynch syndrome may develop colorectal cancer (CRC), despite...
Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are diff...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at incr...
Regular colonoscopy even with short intervals does not prevent all colorectal cancers (CRC) in Lynch...
Background and objective: Despite intensive colonoscopic surveillance, a substantial proportion of L...
Despite colonoscopic surveillance, Lynch syndrome patients develop colorectal cancer (CRC). Identifi...
Colorectal cancer is one of the most common malignancies in the world. A family history of colon ca...
Background and study aims: Patients with Lynch syndrome may develop colorectal cancer (CRC), despite...
Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are diff...